Labeling reagents comprising aphenylic analogs of rhodamine...

Details Labeling reagents comprising aphenylic analogs of rhodamine... Labeling reagents comprising aphenylic analogs of rhodamine...

2007-08-14

2007-08-14

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S165000, C546S270700, C546S271100, C536S023100, C536S026600

Reexamination Certificate

active

10763076

ABSTRACT:
This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.

REFERENCES:
patent: 4375972 (1983-03-01), Forgione et al.
patent: 4683202 (1987-07-01), Mullis et al.
patent: 4707454 (1987-11-01), Hendrix
patent: 4711955 (1987-12-01), Ward et al.
patent: 4868103 (1989-09-01), Stavrianopoulos et al.
patent: 4894325 (1990-01-01), Engelhardt et al.
patent: 4952685 (1990-08-01), Stavrianopoulos et al.
patent: 4978614 (1990-12-01), Bronstein
patent: 4994373 (1991-02-01), Stavrianopoulos et al.
patent: 5013831 (1991-05-01), Stavrianopoulos et al.
patent: 5047519 (1991-09-01), Hobbs et al.
patent: 5118801 (1992-06-01), Lizardi et al.
patent: 5130238 (1992-07-01), Malek et al.
patent: 5132204 (1992-07-01), Urdea et al.
patent: 5210015 (1993-05-01), Gelfand et al.
patent: 5241060 (1993-08-01), Engelhardt et al.
patent: 5248618 (1993-09-01), Haces
patent: 5268486 (1993-12-01), Waggoner et al.
patent: 5270184 (1993-12-01), Walker et al.
patent: 5288609 (1994-02-01), Engelhardt et al.
patent: 5455166 (1995-10-01), Walker et al.
patent: 5455175 (1995-10-01), Wittwer et al.
patent: 5462854 (1995-10-01), Coassin et al.
patent: 5464741 (1995-11-01), Hendrix
patent: 5494810 (1996-02-01), Barany et al.
patent: 5554516 (1996-09-01), Kacien et al.
patent: 5578832 (1996-11-01), Trulson et al.
patent: 5582984 (1996-12-01), Bieniarz et al.
patent: 5599932 (1997-02-01), Bieniarz et al.
patent: 5627027 (1997-05-01), Waggoner et al.
patent: 5646264 (1997-07-01), Glazer et al.
patent: 5707559 (1998-01-01), Schaap et al.
patent: 5730849 (1998-03-01), Hamby et al.
patent: 5849480 (1998-12-01), Cros et al.
patent: 5866336 (1999-02-01), Nazarenko et al.
patent: 5891636 (1999-04-01), Van Gelder et al.
patent: 5945283 (1999-08-01), Kwok et al.
patent: 5945526 (1999-08-01), Lee et al.
patent: 5948648 (1999-09-01), Kahn et al.
patent: 5994056 (1999-11-01), Higuchi
patent: 6001573 (1999-12-01), Roalent
patent: 6004286 (1999-12-01), Bellhouse et al.
patent: 6008373 (1999-12-01), Waggoner et al.
patent: 6110630 (2000-08-01), Reddy et al.
patent: 6114350 (2000-09-01), Randall et al.
patent: 6174670 (2001-01-01), Wittwer et al.
patent: 6221581 (2001-04-01), Engelhardt et al.
patent: 6228578 (2001-05-01), Impraim et al.
patent: 6323337 (2001-11-01), Singer et al.
patent: 6338954 (2002-01-01), Gemen
patent: 0070685 (1982-07-01), None
patent: 0252683 (1995-01-01), None
patent: 0667393 (1995-08-01), None
patent: 0917039 (2000-01-01), None
patent: 1275737 (2003-01-01), None
patent: 1344835 (2003-11-01), None
patent: WO 9928500 (1998-11-01), None
Ball, et al., “The use of tailed octamer primers for cycle sequencing,”Nucl. Acids. Res. 26:5225-5227 (1998).
Baranov, et al., “A new technique for the characterization of long-range tertiary contacts in large RNA molecules: insertion of a photolabel at a selected position in 16S rRNA within theEscherichia coliribosome,”Nucl. Acids Res. 25:2266-2273 (1997).
Dale, R.M., et al., “The synthesis and enzymatic polymerization of nucleotide containing mercury: potential tools for nucleic acid sequencing and structural analysis.”Proc. Natl. Acad. Sci. USA 70:2238-2242 (1973).
Doan, T.L., et al., “Targeted cleavage of polynucleotides by complementary oligonucleotides covalently linked to iron-porphyrins,”Biochemistry 25:6736-6739 (1986).
Eglinton, G., et al., “A coupling of acetylenic compounds,”Adv. Organic Synthesis 4:225-328 (1963).
Ernst, et al., “Cyanine dye labeling reagents for sulfhydryl groups,”Cytometry 10:3-10 (1989).
Fuhrop, J.H., et al., Chapter 19 in “Porphyrins and Metalloporphyrins,” ed. Smith, K.M., Elsevier Science, New York (1975).
Kawase, et al., “Studies on nucleic acid interactions. I. Stabilities of mini-duplexes (dG2A4XA4G2-dC2T4YT4C2) and self-complementary d(GGGAAXYTTCCC) containing deoxyinosine and other mismatched bases,”Nucl. Acids. Res. 14:7727-7736 (1986).
Kuhlmann, K.F., et al., “Synthesis, DNA-binding and biological activity of a double intercalating analog of ethidium bromide,”Nucl. Acids. Res. 5:2629-2633 (1978).
Larock, “Organomercurials in Organic Synthesis,”Tetrahedron 38:1713-1754 (1982).
Lee, L.G., et al., “DNA sequencing with dye-labeled terminators and T7 DNA polymerase: effect of dyes and dNTPs on incorporation of dye-terminators and probability analysis of termination fragments,”Nucl. Acids. Res. 20:2471-2488 (1992).
Liu, H., et al., “PCR amplification using deoxyinosine to replace an entire codon and at ambiguous positions,”Biotechniques 16:24-26 (1994).
Liu, D., et al., “Stable human immunodeficiency virus type 1 (HIV-1) resistance in transformed CD4 + monocytic cells treated with multitargeting HIV-1 antisense sequences incorporated into U1 snRNA,”J. Virol 71:4079-4085 (1997).
Loakes, D., et al., “5-Nitroindole as an universal base analogue,”Nucl. Acids Res. 22:4039-4043 (1994).
Loakes, D., “The applications of universal DNA base analogues,”Nucl. Acids Res. 29:2437-2447 (2001).
Maulding, D.R., et al., “Chemiluminescence from Reactions of Electrophilic Oxamides with Hydrogen Peroxide and Fluorescent Compounds,”J. Org. Chem.33:250-254 (1968).
Moan, J., et al., “Porphyrin photosensitization and phototherapy,”Photochem. Photobio. 43:681-690 (1986).
Mujumdar, R.B., et al., “Cyanine dye labeling reagents containing isothiocyanate groups,”Cytometry 10:11-19 (1989).
Mujumdar, R.B., et al., “Cyanine dye labeling reagents: sulfoindocyanine succinimidyl esters,”Bioconjugate Chemistry 4:105-111 (1993).
Nichols, et al., “A universal nucleoside for use at ambiguous sites in DNA primers,”Nature 369:492-493 (1994).
Okayama, H., et al., “High efficiency cloning of full length cDNA,”Mol. Cell. Biol. 2:161 (1982).
Rieke, R.D., “The preparation of highly reactive metals and the development of novel organometallicreagents,”Aldrichimica Acta 33:52-60 (2000).
Robins, M.J., et al., “Nucleic Acid Related Compounds. 39. Efficient Conversion of 5-lodo to 5-Alkynyl and Derived 5-Substituted Uracil Bases and Nucleosides,”J. Org. Chem. 48:1854-1862 (1983).
Schaap, et al., “Chemical and Enzymatic Triggering of 1,2-Dioxetanes. 1:Aryl Esterase-Catalyzed Chemiluminescence from a Naphthyl Acetate-Substituted 1,2-Dioxetane,”Tetrahedron Letters 28:935-938 (1987).
Schaap, A.P., et al., “Chemical and Enzymatic Triggering of 1,2-Dioxetanes. 3: Alkaline Phosphatase-Catalyzed Chemiluminescence from an Aryl Phosphate-Substituted Dioxetane,”Tetrahedron Letters 28:1159-1163 (1987).
Selinger, D.W., et al., “RNA expression analysis using a 30 base pair resolutionExcherichia coligenome array,”Nature Biotech. 18:1262-1268 (2000).
Shibahara, S., et al., “Site-directed cleavage of RNA,”Nucl. Acids. Res. 15:4403-4415 (1987).
Southwick, P.L., et al., “Cyanine dye labeling reagents—carboxymethylindocyanine succinimidyl esters,”Cytometry 11:418-430 (1990).
Talaat, A.M., et al., “Genome-directed primers for selective labeling of bacterial transcripts for DNA microarray analysis,”Nature Biotech. 18:679-682 (2000).
Tao, et al., “Genomics: Expression Analysis ofEscherichia coliGrowing on Minimal and Rich Media,”J. Bact. 181:6425-6490 (1999).
Wieringa, J.H., et al., “Adamantylideneadamantane Peroxide. A Stable 1,2 Dioxetane,”Tetrahedron Letters 2:169-172 (1972).
Zhu, Z., et al., “Directly labeled DNA probes using fluorescent nucleotides with different

Affiliated with

Also associated with

Rating

Labeling reagents comprising aphenylic analogs of rhodamine... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Labeling reagents comprising aphenylic analogs of rhodamine..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Labeling reagents comprising aphenylic analogs of rhodamine... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3892828