Labeling reactants and their use

Details Labeling reactants and their use Labeling reactants and their use

1998-06-25

2000-06-27

Ceperley, Mary E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

435 6, 436546, 546 82, 546140, 546147, 546256, 546257, 5462704, 5462724, 5462754, 5462804, 546329, 546335, 546336, 546339, 546340, 548545, 560 27, 560 29, C07K 113, G01N 33533, C07D22100

Patent

active

06080839&

ABSTRACT:
The invention relates to a novel labeling reactant, suitable for labeling of a biospecific binding reactant using solid-phase synthesis. The invention further concerns new labeling methods. The novel labeling reactant has the formula (I) ##STR1## wherein -A- is a bivalent aromatic structure capable of absorbing light or energy and transferring the excitation energy to a lanthanide ion after the product made by the said solid-phase synthesis has been released from the used solid support, deprotected and converted to a lanthanide chelate;

REFERENCES:
patent: 4837169 (1989-06-01), Toner
patent: 5324825 (1994-06-01), Kankare et al.
patent: 5571897 (1996-11-01), Takalo et al.
patent: 5859215 (1999-01-01), Rodriguez-Ubis et al.
Erlanger, Methods in Enzymology, vol. 70, Immunochemical Techniques, Part A, 85-104 (1980).
Brinkley, Bioconjugate Chemistry, vol. 3, 2-13 (1992).
Wong, Chemistry of Protein Conjugation and Cross-Linking, Chapter 2 (1991).

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