Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2008-04-01
2008-04-01
Kam, Chih-Min (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S300000, C530S345000, C530S405000, C530S406000, C530S412000, C424S193100, C424S178100
Reexamination Certificate
active
07351797
ABSTRACT:
The invention provides intermediates and methods that allow for site-specific modification of peptides after synthesis. Accordingly, functional molecules can be selectively linked to a peptide to provide a peptide conjugate having altered biological, chemical, or physical properties. For example, functional molecules (e.g. biophysical probes, peptides, polynucleotides, and therapeutic agents) can be linked to a peptide to provide a peptide conjugate having differing and useful properties. The invention also provides a compound of formula (III):wherein:R6is a peptide;X is a direct bond or a linking group;R7is hydrogen, (C1-C6)alkyl, an amino protecting group, or a radical comprising one or more aminooxy groups;Y is a direct bond or a linking group; andD is a functional molecule.
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Bark Steven J.
Hahn Klaus M.
Kam Chih-Min
Schwegman Lundberg & Woessner, P.A.
The Scripps Research Institute
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