Labeled neurotensin derivatives

Details Labeled neurotensin derivatives Labeled neurotensin derivatives

2006-03-21

2006-03-21

Weber, Jon (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

C530S323000, C530S327000, C514S014800, C514S016700, C514S017400, C424S001110, C424S001570, C424S001690, C424S009100, C435S007230, C435S007720

Reexamination Certificate

active

07015306

ABSTRACT:
Peptide analogs of neurotensin are disclosed which are resistant to enzymatic degradation and which retain high binding affinity for neurotensin receptors. Pharmaceutical compositions of these compounds are useful for diagnostic and therapeutic purposes.

REFERENCES:
patent: 0606804 (1994-07-01), None
patent: WO 95/22341 (1995-08-01), None
Visser et al., Eur. J. Nucl. Med. Mol. Imaging, vol. 30, No. 8, pp. 1134-1139, Aug. 2003.
Achilefu et al., J. Med. Chem., vol. 46, No. 15, pp. 3403-3411, 2003.
Chavatte, K.; Wong, E.; Fauconnier, T.K.; Lu, L.; Nguyen, T.; Roe, D.; Pollack, A.; Eshima, D.; Terriere, D.; Mertens, J.; Iterbeke, K., Tourwe, D.; Thornback, J.; Bossuyt, A.; Rhenium (Re) and Technetium (Tc)-99m Oxocomplexes of Neurotensin (8-13), 6001, vol. 131, Chemical Abstracts (Abstract No. 99344y), No. 8; 1999; Columbus, Ohio, USA.
Chavatte, K.; Wong, E.; Fauconnier, T.K.; Lu, L.; Nguyen, T.; Roe, D.; Pollack, A.; Eshima, D.; Terriere, D.; Mertens, J.; Iterbeke, K., Tourwe, D.; Thornback, J.; Bossuyt, A.; Rhenium (Re) and Technetium (Tc)-99m Oxocomplexes of Neurotensin (8-13), Journal of Labelled Compounds and Radiopharmaceuticals, Abstract, vol. 42, No. 5, pp. 415-421; 1999; John Wiley & Sons, Ltd., USA.

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