Labeled DNA

Details Labeled DNA Labeled DNA

1983-09-02

1986-12-02

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 23, 536 26, 544264, 544269, 544272, 935 77, 935 78, C12Q 168, C07H 1700, C07H 1900, C07D47300

Patent

active

046265015

ABSTRACT:
Polymeric, single-stranded DNA molecule which is labeled with a plurality of labels, the labels being bonded, via linking groups, to adenine and cytosine bases of the DNA molecule in substantially equal numbers, the labels being bonded to essentially none of the guanine or thymine bases of the DNA molecule, the DNA molecule being adapted for use as a probe in a nucleic acid hybridization assay.

REFERENCES:
patent: 4139346 (1979-02-01), Rabbani
patent: 4228237 (1980-10-01), Hevey et al.
patent: 4282287 (1981-08-01), Giese
patent: 4286964 (1981-09-01), Seed
patent: 4358535 (1982-11-01), Falkow et al.
Fink et al. (1980) Analytical Biochemistry 108, 394-401.
Grunstein et al. (1975) Proc. Nat. Acad. Sci. USA 72(10), 3961-5.
Hsu et al. (1981) Jour. Histochem. and Cytochem. 29(4), 577-580.
Manning et al. (1975) Chromosoma 53, 107-117.
Sodja et al. (1977) Nucleic Acids Research, pp. 385-401.
Broker et al. (1977) Nucleic Acids Research, pp. 363-384.
Langer et al. (1981) Proc. Natl. Acad Sci USA 78(11), 6633-6637.
Langer-Safer et al. (1982) Proc. Natl. Acad. Sci. USA 79, 4381-5.
Renz (1983) BMBO Journal 2(6), 817-822.

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