Labeled cocaine analogs

Details Labeled cocaine analogs Labeled cocaine analogs

1997-10-10

1999-03-30

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 189, 546132, 206223, A61K 5104, A61K 3146, C07D45102

Patent

active

058884750

ABSTRACT:
Novel methods for positron emission tomography or single photon emission spectroscopy using tracer compounds having the structure: ##STR1## where X in .beta. configuration is

REFERENCES:
patent: 5128118 (1992-07-01), Carroll et al.
patent: 5310912 (1994-05-01), Neumeyer et al.
patent: 5380848 (1995-01-01), Kuhar et al.
C!cocaine metabolites contribute to PET images of the baboon brain," J. Neurochem. 62:1154-1162.
Clark et al. (1973) "Compounds affecting the central nervous system. 4.3.beta.-phenyltropane-2-carboxylic esters and analogs," J. Med. Chem. 16:1260-1267. H!2.beta.-carbomethoxy-3.beta.-(4-fluorophenyl)tropane," Mol. Pharmacol. 36:518-524.
Davies et al. (1994) "Synthesis of affinities at dopamine and serotonin transport sites in rat striatum and frontal cortex," J. Med. Chem. 37: 1262-1268.
Milius et al. (1991) "Synthesis of receptor binding of n-substituted tropane derivatives. High-affinity ligands for the cocaine receptor," J. Med. Chem. 34:1728-1731.
Madras et al. (1990) "N-modified fluorophenyltropane analogs with high affinity for cocaine receptors," Pharmacology Biochemistry and Behavior 35:949-953.
Dannals et al. (1992) "Synthesis of radiotracer for studying dopamine uptake sites in vivo using PET: Radiopharmaceuticals 33:147-152.
Calne et al. 91985) "Positron emission tomography after MPTP: observations relating to the cause of Parkinson's disease," Nature 317:246-248.
Goodman et al. (1995) J. Nucl. Med. 36:38P, Abstract No. 150 (Proceedings of the 42nd Annual Meeting of the Society of Nuclear Medicine, Minneapolis, MN, Jun. 12-15.

Affiliated with

Also associated with

Rating

Labeled cocaine analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Labeled cocaine analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Labeled cocaine analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1211503