Labeled cells for use in imaging

Details Labeled cells for use in imaging Labeled cells for use in imaging

1988-08-04

1990-06-19

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, A61K 4902, A61K 4900

Patent

active

049352237

ABSTRACT:
A process is provided for the labeling of viable eucaryotic cells. The process includes the steps of collecting, separating, and introducing a quantity of first type cells into a non-toxic media suitable to conduct an electric field. A labeling material is added to this media. The media containing the first type cells and the labeling material is pulsed for a period of time with an electric field, sufficient to render the cell membranes permeable so that the labeling material permeates the cells and becomes trapped therein upon cessation of the pulsing to produce labeled cells. Also provided is a process for diagnostically imaging pathological sites in a patient. This process contains the additional steps of administering the labeled cells to a patient and monitoring the localization of the labeling material in the patient to image the locus of a specific pathosis.

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