Labeled 5,5-diphenylhydantoin derivatives for radioimmunoassay

Details Labeled 5,5-diphenylhydantoin derivatives for radioimmunoassay Labeled 5,5-diphenylhydantoin derivatives for radioimmunoassay

1977-09-22

1979-03-20

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 424 12, 548309, 548312, G01N 3316, A61K 4300

Patent

active

041454073

ABSTRACT:
Derivatives of 5,5-diphenylhydantoin having the following structural formula: ##STR1## where R is 2-acetyl, 3-propionyl, 4-butyryl or 5-valeryl and X is an unlabeled or radioiodinated amino radical; e.g., (tyrosine, histidine, tyrosinol, histamine). A preferred compound is radioiodinated 5,5-diphenyl-3-(5-valeryl-N-tyrosine) hydantoin. The iodine isotope may be iodine -125 or iodine-131.

REFERENCES:
patent: 4073926 (1978-02-01), Sonntag et al.
Orme et al., Clinical Chemistry, vol. 22, No. 2, Feb. 1976, pp. 246-249.

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