Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2007-01-19
2011-11-15
Hartley, Michael G (Department: 1618)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S006120
Reexamination Certificate
active
08057989
ABSTRACT:
The present invention provides a composition for detecting and/or characterizing a multiple-charged biomolecule comprising a charged d8or d10metal complex, wherein the metal complex electrostatically binds to the multiple-charged biomolecule to induce aggregation and self-assembly of the metal complex through metal . . . metal interactions, π . . . π interactions, or a combination of both interactions. The present invention further provides assay methods and kits for label-free optical detection and/or characterization of biomolecules carrying multiple charges, e.g., single-stranded nucleic acids, polyaspartate, polyglutamate, using a composition comprising a charged d8or d10metal complex.
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Chan Kenneth Hoi-Yiu
Wong Keith Man-Chung
Yam Vivian Wing-Wah
Yu Cong
Cooper & Dunham LLP
Hartley Michael G
Katz Robert D.
Perreira Melissa
The University of Hong Kong
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