Label-free evanescent-field detection of biological and...

Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing

Reexamination Certificate

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C385S012000, C385S030000, C422S082050, C422S082110, C435S006120, C435S005000, C435S287900, C435S288700, C435S808000, C436S514000, C436S524000, C436S525000, C436S527000, C436S528000, C436S529000, C436S805000

Reexamination Certificate

active

07368281

ABSTRACT:
An evanescent-field sensor system and method of using the system to detect either liquid- or airborne biological pathogens, chemical agents, and other harmful or toxic species is provided. The sensor system involves 1) an evanescent-field sensor having a substrate surface with at least a partial bio- or chemo-responsive layer, which forms a part of a serially renewable sensing region; 2) an optical interrogation apparatus for monitoring the bio- or chemo-responsive layer; and 3) an air-fluid delivery system. The optical interrogation apparatus has a light source, an optical delivery system, and a detection instrument or device. The air-fluid delivery system includes either macro or micro-fluidic passages designed to convey biological or chemical analytes to a sensing region.

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