Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2005-02-01
2005-02-01
Riley, Jezia (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S006120, C435S110000
Reexamination Certificate
active
06849397
ABSTRACT:
Disclosed is a method to detect unlabeled nucleic acids (DNA and/or RNA) in a taxa, species, and organelle-specific fashion using surface plasmon resonance (SPR) imaging. Taxa-specific, species-specific, or organelle-specific nucleic acids are affixed to an SPR-suitable substrate. A nucleic acid sample to be analyzed is then contacted with the SPR-substrate and the substrate analyzed to determine the presence or absence of specific hybridization between the nucleic acids bound to the substrate and the nucleic acids contained in the sample. The method does not require that either the bound nucleic acids nor the sample nucleic acids be labeled. The method can be used to identify the source of nucleic acids, their sequence, as well as to identify organisms and place them within a given taxonomic hierarchy.
REFERENCES:
patent: 5374563 (1994-12-01), Maule
patent: 5629213 (1997-05-01), Kornguth et al.
patent: 5837832 (1998-11-01), Chee et al.
patent: 6060237 (2000-05-01), Nygren et al.
patent: 6127129 (2000-10-01), Corn et al.
patent: 6228580 (2001-05-01), Blumenfeld et al.
patent: 6232068 (2001-05-01), Linsley et al.
patent: 6472148 (2002-10-01), Bamdad et al.
patent: 6537749 (2003-03-01), Kuimelis et al.
patent: 6579726 (2003-06-01), Natan et al.
patent: 0 305 108 (1989-03-01), None
Amann et al. (1990) Fluorescent-Oligonucleotide Probing of Whole Cells for Determinative, Phylogenetic, and Environmental Studies in Microbiology,J. Bacteriol. 172:762-770.
Anderson et al. (2000) Fabrication of Topologically Complex Three-Dimensional Microfluidic Systems in PDMS by Rapid Prototyping,Anal. Chem. 72:3158-3164.
Brockman et al. (1999) A Multistep Chemical Modification Procedure to Create DNA Arrays on Gold Surfaces for the Study of Protein—DNA Interactions with Surface Plasmon Resonance Imaging,J. Am. Chem. Soc.121:8044-8051.
Brockman et al. (2000) Surface Plasmon Resonance Imaging Measurements of Ultrathin Organic Films,Ann. Rev. Phys. Chem.51:41:63.
Duffy et al. (1998) Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane)Anal. Chem.70:4974-4984.
Effenhauser et al. (1997) Integrated Capillary Electrophoresis on Flexible Silicone Microdevices: Analysis of DNA Restriction Fragments and Detection of Single DNA Molecules on Microchips,Anal. Chem.69:3451-3457.
FODOR (1997)Science277:393-395.
Frutos et al. (1997) Demonstration of a word design strategy for DNA computing on surfaces,Nucleic Acids Res.25:4748-4757.
Frutos et al (1998) Enzymatic Ligation Reactions of DNA “Words” on Surfaces for DNA Computing,J. Am. Chem. Soc.120:10277-10282.
Frutos et al. (1998) SPR of Ultrathin Organic Films,Anal. Chem.70:449A-455A.
Frutos et al. (2000) Reversible Protection and Reactive Patterning of Amine-and Hydroxyl-Terminated Self-Assembled Monolayers on Gold Surfaces for the Fabrication of Biopolymer Arrays,Langmuir16:2192-2197.
Hickel et al. (1989) Surface-plasmon microscopy,Nature339:186.
Jordan et al. (1997) Surface Plasmon Resonance Imaging Measurements of DNA Hybridization Adsorption and Streptavidin/DNA Multilayer Formation at Chemically Modified Gold Surfaces,Anal. Chem.69:4939-4947.
Jordan et al. (1997)Anal Chem.69(7):1449-1456.
Lockhart, et al. (1996) Expression monitoring by hybridization to high-density oligonucleotide arrays,Nature Biotechnology14:1675-1680.
Nelson et al. (1999) Near-Infrared Surface Plasmon Resonance Measurements of Ultrathin Films. 1. Angle Shift and SPR Imaging Experiments,Anal. Chem.71:3928-3934.
Nelson et al. (2001) Surface Plasmon Resonance Imaging Measurements of DNA and RNA Hybridization Adsorption onto DNA Microarrays,Anal. Chem.73:1-7.
Pease et al. (1994) Light-generated oligonucleotide arrays for rapid DNA sequence analysis,Proc. Natl. Acd. Sci. USA91:5022-5026.
Rothenhäusler&Knoll (1988) Surface-Plasmon microscopy,Nature332:615-617.
Silin & Plant (1997) Biotechnological applications of surface plasmon resonance,Trends in Biotechnol.15.
Strother et al. (2000) Covalent attachment of oligodeoxyribonucleotides to amine-modified Si (001) surfaces,Nucleic Acids Research28:3535-3541.
Tarlov et al. (1993) UV Photopatterning of Alkanethiolate Monolayers Self-Assembled on Gold and Silver,J. Am. Chem. Soc.115:5305-5306.
Thiel et al. (1997) In Situ Surface Plasmon Resonance Imaging Detection of DNA Hybridization to Oligonucleotide Arrays on Gold Surfaces,Anal Chem.69:4948-4956.
Thomas et al. (1995) Probing Adhesion Forces at the Molecular Scale,J. Am. Chem. Soc.117:3830-3834.
Winzeler et al. (1998) Direct Allelic Variation Scanning of the Yeast Genome,Science281:1194-1197.
Corn Robert M.
Frederick Kendra
Goodman Robert M.
Liles Mark R.
Nelson Bryce P.
DeWitt Ross & Stevens S.C.
Leone, Esq. Joseph T.
Riley Jezia
Wisconsin Alumni Research Foundation
LandOfFree
Label-free detection of nucleic acids via surface plasmon... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Label-free detection of nucleic acids via surface plasmon..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Label-free detection of nucleic acids via surface plasmon... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3476587