Labdanes and process for their preparation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514255, 514320, 514455, 514912, 544150, 544375, 546196, 549389, A61K 31535, A61K 31495, A61K 31445, A61K 3135

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active

052062414

ABSTRACT:
Labdanes of the formula ##STR1## a process for their manufacture, pharmaceutical preparations containing an effective amount of these compounds and their use for the manufacture of a pharmaceutical preparation for treatment of cardiovascular diseases and high intraocular pressure.

REFERENCES:
patent: 4088659 (1978-05-01), Bhat et al.
patent: 4118508 (1978-10-01), Bhat et al.
Bhat, et al., "Reactions of Forskolin, a Biologically Active Diterpenoid from Coleus Forskohlii", Perkin Trans. 1, pp. 767-771 (1982).
Bhat, et al., "Structures and Stereochemistry of New Labdane Diterpenoids from Coleus Forskohlii Briq.", Tetrahedron Letters No. 19, Pergamon Press, pp. 1669-1672 (1977).
Khandelwal, et al., "Cardiovascular Effects of New Water-Soluble Derivatives of Forskolin", J. Med. Chem., vol. 31, pp. 1872-1879 (1988).

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