Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1998-05-11
1999-11-30
Degen, Nancy
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
435474, 435476, C12N 1563, C12N 1574
Patent
active
059941375
ABSTRACT:
This invention is directed to L5 shuttle phasmids capable of delivering foreign DNA into mycobacteria and to methods of producing L5 shuttle phasmids. In addition, this invention is directed to a method of generating mycobacterial mutations and to a method of producing mycobacterial vaccines.
REFERENCES:
patent: 5504005 (1996-04-01), Bloom et al.
Kalpana et al. (1991) Insertional mutagenesis and illegitimate recombination in mycobacteria. Proc. Natl. Acad. Sci USA 8:5433-5437, Jun., 1991.
Bardarov Stoyan
Hatfull Graham F.
Jacobs William R.
McAdam Ruth
Albert Einstein College of Medicine of Yeshiva University
Degen Nancy
Schwartzman Robert
University of Pittsburgh
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