Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Patent
1998-01-21
2000-10-17
Guzo, David
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
4352523, 43525233, 4353201, 536 232, 536 237, C07H 2104, C12N 121, C12N 1570, C12N 1573, C12P 1308
Patent
active
061329991
ABSTRACT:
The present invention provides a novel microbial strain and a method for effectively producing L-threonine. The novel strain can grow on a medium containing molasses, a much cheaper raw material than sucrose. The exemplary novel strain E. coli BKIIM B-5318 bears the plasmid pPRT614, which has threonine biosynthesis genes (thr A, B and C), the expression of which is regulated by a lambda-phage PR promoter and temperature-sensitive C1 repressor. The present microorganism is prototrophic with regard to isoleucine. The strain E. coli BKIIM B-5318 produces more than 70 g/l of L-threonine when cultured at 38-41.degree. C. for 32 hours in a medium containing molasses.
Bachina Tatiana Alexandrovna
Christoserdov Andrei Yurevich
Debabov Vladimir Georgievich
Gavrilova Oksana Fedorovna
Gusyatiner Michail Markovich
Ajinomoto Co. Inc.
Guzo David
Larson Thomas G
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