L-Proline production from algae

Details L-Proline production from algae L-Proline production from algae

1981-12-10

1983-05-10

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435946, C12P 1324, C12R 189

Patent

active

043830390

ABSTRACT:
A process for recovering L-proline from Chlorella sp. 580 algae without disrupting the L-proline synthesizing capability of the algae thereby permitting reuse of the proline depleted cells to produce additional amounts of L-proline. The process comprises cultivating Chlorella sp. 580 algae under high-intensity illumination in an aqueous growth medium containing a high concentration of sodium chloride (at least 1 M in the final stage of cultivation), providing an adequate supply of carbon, in a depth not exceeding approximately 20 cm of the aqueous medium, until algae of high L-proline content are obtained, harvesting the algae and thereafter diluting the harvested algae with water to a concentration below at least 0.3 M NaCl to effect the release of L-proline from the algae into the aqueous phase, removing the algae from the L-proline containing aqueous solution and reintroducing the algae into a high salt concentration containing medium of up to at least 1 M NaCl to restimulate L-proline production within the algae.

REFERENCES:
patent: 3650068 (1978-03-01), Meyer et al.
patent: 4224409 (1980-09-01), Nakamori et al.
Aust. J. Plant Physiology, 1979, vol. 6, pp. 69-79.
Limnol. Oceanographer, vol. 10, pp. 192-206 (1965).

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