Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1994-08-05
1996-07-16
Jacobson, Dian C.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435193, 4353171, C12N 910, C12N 113, C12N 1554, C12N 1563
Patent
active
055366520
ABSTRACT:
L-Phenylalanyl-tRNA synthetase mutants, a process for the preparation thereof and the use thereof for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins.
The invention relates to L-phenylalanyl-tRNA synthetases from microorganisms which, by reason of a modification generated by genetic engineering, have an altered substrate selectivity, and to their preparation and use for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins.
REFERENCES:
3P. Kast et al., "Amino Acid Substrate Specificity of Escherichia coli Phenylalanyl-tRNA Synthetase Altered by Distinct Mutations," J. Mol. Biol. 222:99-124 (1991).
Dissertation ETH Nr. 9468, "Investigations on Escherichia coli Phenylalanyl tRNA Synthetase at the Molecular Level: Identification and Genetic Engineering of a Phenylalanine Specificity Determinant and Possible Application of a Relaxed Specificity Mutant," presented by Peter Kast to Swiss Federal Institute of Technology Zurich (1991).
Hennecke Hauke
Kast Peter
Hoechst Aktiengesellschaft
Jacobson Dian C.
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