Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1992-01-21
1994-12-06
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435193, 435 914, 4351723, 4352523, 43525233, 4353201, 536 232, 935 10, 935 44, C12N 910, C12N 1512, C12N 1554, C12P 2100
Patent
active
053709950
ABSTRACT:
L-Phenylalanyl-tRNA synthetase mutants, a process for the preparation thereof and the use thereof for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins.
The invention relates to L-phenylalanyl-tRNA synthetases from microorganisms which, by reason of a modification generated by genetic engineering, have an altered substrate selectivity, and to their preparation and use for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins.
REFERENCES:
P. Kast et al., "Amino Acid Substrate Specificity of Escherichia coli Phenylalanyl-tRNA Synthetase Altered by Distinct Mutations," J. Mol. Biol. 222: 99-124 (1991).
Dissertation Eth Nr. 9468, "Investigations on Escherichia coli Phenylalanyl tRNA Synthetase at the Molecular Level . . . ", presented by Peter Kast to the Swiss Federal Institute of Technology Zurich (1991).
Hennecke Hauke
Kast Peter
Hoechst Aktiengesellschaft
Jacobson Dian C.
Wax Robert A.
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