Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1992-03-26
1993-11-30
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514869, A61K 31195
Patent
active
052665968
ABSTRACT:
DL- or L-threo-3-(3,4-dihydroxyphenyl)serine is effective for the treatment of urinary incontinence, shows no side effects such as urine discharge disturbance, palpitation and hypertension, and has low toxicity.
REFERENCES:
patent: 4647587 (1989-03-01), Katsube et al.
Urology, vol. 5, No. 5, 1975, pp. 624-625; A. C. Diokno et al.: "Ephedrine in Treatment of Urinary Incontinence".
Scandinavian Journal of Urology and Nephrology, vol. 12, No. 2, 1978, pp. 105-110; K. E. Andersson et al "The Effects of Long-Term Treatment with Norephedrine on Stress Incontinence and Urethral Closure Pressure Profile".
The Japanese Journal of Pharmacology, vol. 52, No. 3, Mar., 1990; pp. 431-439; S. Morimoto et al, "Diuretic Effects of L-Threo-3,4-Dihydroxyphenylserine in Anesthetized Rats".
STN File Supplier, Medline AN-89280494, 1989, and Nippon Hinyokika Gakkai Zasshi vol. 80, No. 3, 1989 Japan pp. 416-423; Morita T.: `Experiment Studies on Urinary Incontinence`.
PH. Dorosz "Guide Pratique Des Medicaments" 1987, Maloine S. A. Editeur, Paris pp. 848-849.
Scandinavian Journal of Urology and Nephrology, vol. 17, No. 3, 1983, pp. 261-265; K. E. Andersson et al: "The Effect of Mododrine and Its Active Metabolite ST 1059 on the Human Urethra In Vitro and In Vivo".
Hayashi et al, "Effect of Oral L-threo-3,4-dihydroxyphenylserine on Patients with Severe Orthostatic Hypotention Secondary to Autonomic Neuropathy," The Journal of the Japan Diabetes Society, vol. 29, No. S1, 1986.
J. E. F. Reynolds `Martindale, The Extra Pharmacopoeia` 1989, The Pharmaceutical Press, London "DL-Threo-3,4-Dihydroxyphenylserine", p. 1564.
The Lancet, 1987, pp. 1170-1172, I. Biaggioni et al: "Endogenous Restoration of Noradrenaline by Precursor Therapy in Dopamine-Beta-Hydroxylase Deficiency".
N. Yoshimura et al, "Contraction of Urinary Bladder by Central . . . the Locus Coeruleus", The Journal of Urology, vol. 139, Feb., 1988, pp. 423-427.
R. Freeman et al, "The Treatment of Orthostatic Hypotension with Dihydroxyphenylserine", Clinical Neuropharmacology, vol. 14, No. 4, 1991, pp. 296-304.
N. Yoshimura et al, "Mediation of Micturition Reflex . . . Coeruleus in the Cat", The Journal of Urology, vol. 143, Apr., 1990, pp. 840-843.
Takaori Shuji
Yokokawa Kiyoshi
Criares T. J.
Sumitomo Pharmaceuticals Co. Ltd.
Waddell Frederick E.
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