L-methionine $g(g)-lyase with modified function

Details L-methionine $g(g)-lyase with modified function L-methionine $g(g)-lyase with modified function

2006-10-10

2006-10-10

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Lyase

C435S006120, C435S069100, C435S320100, C536S023200

Reexamination Certificate

active

07118903

ABSTRACT:
An L-methionine γ-lyase having modified function which is obtained by structurally stabilizing natural L-methionine γ-lyase by analyzing the structure of crystals thereof by using X-ray, estimating an amino acid sequence concerning its substrate specificity and varying amino acid residue thereof; enzymes comprising a protein constituting the L-methionine γ-lyase having modified function or its multimer (preferably its tetramer); DNA sequences encoding these enzymes; a process for producing these enzymes; and medicinal preparations (preferably anticancer agent) containing these enzymes.

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