L-lysyl-glycyl-L-histidine and therapeutic agent for wound heali

Details L-lysyl-glycyl-L-histidine and therapeutic agent for wound heali L-lysyl-glycyl-L-histidine and therapeutic agent for wound heali

1995-05-19

1997-01-07

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530331, C07K 509, A61K 3806

Patent

active

055917119

ABSTRACT:
L-lysyl-glycyl-histidine and metal complexes thereof, for example, L-lysyl-glycyl-L-histidine: copper (II).
The L-lysyl-glycyl-L-histidine and salt thereof have a fibroblast proliferation promoting activity and then it is useful as a wound healing agent.

REFERENCES:
patent: 4760051 (1988-07-01), Pickart
patent: 5023237 (1991-06-01), Pickart
patent: 5118665 (1992-06-01), Pickart
patent: 5164367 (1992-11-01), Pickart
patent: 5386012 (1995-01-01), Strid
Dijke et al., "Growth Factors For Wound Healing", Bio/Technology, vol. 7:793-799, (1989).
Pickart et al., "Biological Activity Of Human Plasma Copper-Binding Growth Facor Glycyl-L-histidyl-L-lysine", Methods In Enzymology, vol. 147:314-328, (1987).
Pickart, "The Use Of Glycylhistidyllysine In Culture Systems", In Vitro, vol. 17, No. 6, pp. 459-466, (1981).
Audhya et al., "Tripeptide Structure of Bursin, A Selective B-Cell-Differentiating Hormone of The Bursa of Fabricius", Science, vol. 231:997-999, (1986).
Lote et al., "An Inhibitory Tripeptide From Cat Spinal Cord", Nature, vol. 264:188-189, (1976).
Runyan et al. "The Journal of Cell Biology", vol. 125, No. 4, May, 1994 pp. 928-943.

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