L-isoleucine-producing bacterium and method for preparing L-isol

Details L-isoleucine-producing bacterium and method for preparing L-isol L-isoleucine-producing bacterium and method for preparing L-isol

1995-05-26

1999-12-07

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

43525233, C12P 1306, C12N 121

Patent

active

059981784

ABSTRACT:
An L-isoleucine-producing bacterium belonging to the genus Escherichia which carries a thrABC operon which comprises a thrA gene coding for aspartokinase I-homoserine dehydrogenase I substantially released from the inhibition by L-threonine and an ilvGMEDA operon which comprises an ilvA gene coding for threonine deaminase substantially released from the inhibition by L-isoleucine and whose region required for attenuation is removed; and an L-isoleucine-producing bacterium belonging to the genus Escherichia carrying the thrABC operon, an lysC gene coding for aspartokinase III substantially released from the inhibition by L-lysine, and the ilvGMEDA operon. The bacteria permit biosynthesis of a sufficient amount of L-isoleucine.

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WPI 94-183516/22 (WO 94/11517), 1994.
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