L-erythrosyl nucleosides

Details L-erythrosyl nucleosides L-erythrosyl nucleosides

1994-10-24

1997-09-30

Wilson, James O.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 46, 514 49, 514 50, 536 2714, 536 2721, 536 276, 536 2761, 536 2762, 536 2763, 536 277, 536 278, 536 2781, 536 281, 536 285, 536 2851, 536 2852, 536 2853, 536 2854, 536 2855, A61K 3170

Patent

active

056725949

ABSTRACT:
This invention relates to .alpha. and .beta.-L-erythrosyl nucleosides of the formula (I), wherein the nucleoside substitution on the erythrosyl carbohydrate molecule comprises a substituted or unsubstituted purine (adenine or guanine) or pyrimidine (cytosine, uracil, thymine and hypoxanthine) base. Also provided are methods to make the .alpha. and .beta.-L-erythrosyl nucleosides and methods of using such to treat cancer in a mammal.

REFERENCES:
patent: 5075446 (1991-12-01), Kim et al.
Ozaki, S. et al. (2986) Chem & Pharma. Bull. 34(1):150-157.
Miwa, M. et al. (1986) Chem. & Pharma. Bull. 34(10):4225-4232.
Phadtare, S. et al. (1989) J. Am. Chem. Soc. 111(15):5925-5931.
Chemical Abstracts (986) No. 226624e 105(25):798.
Lee, C.H. et al. (1990) Heterocycles 31(1):211-214.
Chemical Abstracts (1977)No. 168348q 87(21):609.
Chemical Abstract (1980) No. 168560b 93(17):711.
Chemical Abstracts (1979) No. 175368p 91(21):670.
Chemical Abstracts (1980) No. 59160e 92(7):714.
Chemical Abstracts (1986) No. 60481d 105(7):602.
Chemical Abstracts (1987) No. 115913v 107(13):662.
Chemical Abstracts (1988) No. 132218k 108(15):797.
Noell, C.W. et al., (1968) J. Heterocyclic Chem. 5(1)25-28.

Affiliated with

Also associated with

Rating

L-erythrosyl nucleosides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with L-erythrosyl nucleosides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and L-erythrosyl nucleosides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2256738