L-dopa derivatives or their acid addition salts, process for pro

Details L-dopa derivatives or their acid addition salts, process for pro L-dopa derivatives or their acid addition salts, process for pro

1988-09-16

1990-10-30

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

260404, 514512, 514529, 514530, 514544, 514532, 514546, 514549, 514552, 558271, 560 1, 560 55, 560 65, 560 73, 560105, 560109, 560122, 560123, 560124, 560125, 560126, 560142, C07C 6900, A61K 31215

Patent

active

049669150

ABSTRACT:
An L-dopa derivative represented by formula (I) ##STR1## wherein one of R.sup.1 and R.sup.2 denotes a hydrogen atom and the other denotes a group of formula R--CO-- in which R denotes an alkyl, alkenyl, optionally substituted cycloalkyl, optionally substituted phenyl, optionally substituted aralkyl, lower alkoxy or optionally substituted aralkyloxy group,
and its acid addition salt. The compounds are useful in the medical field, especially in the treatment of a series of diseases called Parkinson's disease or Parkinsonism.

REFERENCES:
patent: 2868818 (1959-01-01), Pfister
patent: 3725470 (1973-04-01), Bretschneider
patent: 3859331 (1975-01-01), Kaiser
patent: 3891696 (1975-06-01), Bodor
patent: 3983138 (1976-09-01), Saari
patent: 4311706 (1982-01-01), Bodor
Roche, "Design of Biopharmaceutical Properties through Prodrugs and Analogs".

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