L-.beta.-dioxolane uridine analog administration for treating Ep

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514 50, 514 51, 536 2623, 536 2626, 536 268, 536 2853, 536 2854, 536 2588, 544242, 544243, A61K 31505, A61K 3170, C07D47300, C07H 1910

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active

057927731

ABSTRACT:
The present invention relates to the discovery that certain .beta.-L-dioxolane nucleoside analogs which contain a uracil base, and preferably, a 5-halosubstituted uracil base, exhibit unexpectedly high activity against Epstein-Barr virus (EBV). In particular, the compounds according to the present invention show potent inhibition of the replication of the virus (viral growth) in combination with very low toxicity to the host cells (i.e., animal or human tissue). Compounds are useful for treating EBV infections in humans.

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