L-Argininal derivatives and a method of manufacturing the same

Details L-Argininal derivatives and a method of manufacturing the same L-Argininal derivatives and a method of manufacturing the same

1981-09-08

1983-08-30

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

044015941

ABSTRACT:
L-Argininal derivatives of the general formula: ##STR1## are disclosed. A method of manufacturing any such derivative is also disclosed. The L-argininal derivative of this invention has a strong inhibitory activity on proteases, such as serine and thiol proteases, and is expected to provide useful medicines, including those which are effective for diseases caused by abnormal elevation of protease activity.

REFERENCES:
patent: 3840513 (1974-10-01), Umezawa et al.
Biol. Abstr., vol. 65, 35256 (1978).
Chem. Abstr., vol. 77, (1972) 165066d.
Chem. Abstr., vol. 83, (1975) 43760d.
Chem. Abstr. vol. 83, (1975) 10882s.
Chem. Abstr., vol. 76, (1972) 46521t.
Chem. Pharm. Bull. 23, (12) 3081-3087, 3106-3113 (1975).
Biochimica et Biophysica Acta 525, (1978) 429-437.

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