L-argininal acetal derivatives and a process for production ther

Details L-argininal acetal derivatives and a process for production ther L-argininal acetal derivatives and a process for production ther

1991-09-05

1995-05-16

Robinson, Allen J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C20978

Patent

active

054162386

ABSTRACT:
Novel N.sup.G -protected or unprotected-L-argininal-dibutyl acetals (I) can be prepared from L-argininal derivatives (III) merely by reacting in an azeotropic solvent in the presence of p-toluenesulfonic acid. In the products (I), L-form amounts to more than 99%, without further optical resolution. The L-argininal acetals (I) are useful as starting materials for preparing peptidyl-L-argininal derivatives which can provide protease inhibitors or ligands used for affinity chromatography of various proteases.

REFERENCES:
patent: 3429919 (1969-02-01), Koopman et al.
patent: 5296498 (1994-03-01), Malen et al.
Carey, Francis Organic Chemistry McGraw-Hill Pub. (1987) p. 657.
Morrison & Boyd, Organic Chemistry (3rd Ed.) Allyn & Bacon, Inc. (1973) p. 641.

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