L-amino acid oxidase with cytotoxic activity from Aplysia...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase

Reexamination Certificate

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Details

C435S069100, C435S325000, C435S320100, C536S023200

Reexamination Certificate

active

07407784

ABSTRACT:
The present invention relates to a cytotoxic polypeptide which is an L-amino acid oxidase isolated from the ink of the sea hareAplysia punctata.

REFERENCES:
patent: 6171818 (2001-01-01), Petzelt
patent: 6372211 (2002-04-01), Isaac et al.
patent: 2004/0101940 (2004-05-01), Butzke et al.
patent: WO 97/16457 (1997-05-01), None
patent: WO 02/31144 (2002-04-01), None
patent: WO 03/057726 (2003-07-01), None
Petzel T et al: “Cytotoxic Cyplasin of the Sea Hare,Aplysia punctata, CDNA Cloning, and Expression of Bioactive Recombinants in Insect Cells” Neoplasia, Doyma, Barcelona, ES, vol. 4, No. 1, Jan. 2002, pp. 49-59, XP008016612; ISSN: 0212-9787.
Yamazaki: “Antitumor and Antimicrobial Glycoproteins From Sea Hares” Comperative Biochemistry and Physiology, Elmsford, NY, US, vol. 105C, No. 2, 1993, pp. 141-146, XP002034987.
Yamazaki et al: “Purification of a Cytolytic Factor From Purple Fluid of a Sea Hare” FEBS Letters, Elsevier Science Publishers, Amsterdam, NL, vol. 198, No. 1, Mar. 1986, pp. 25-28, XP001002735, ISSN: 0014-5793.

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