Kynurenic acid derivatives useful in the treatment of neurodegen

Details Kynurenic acid derivatives useful in the treatment of neurodegen Kynurenic acid derivatives useful in the treatment of neurodegen

1992-07-20

1993-12-14

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514312, 544128, 546153, 546156, 564305, 564441, 564442, 568936, 568939, A61K 31535, A61K 3147, C07D40112, C07D41312

Patent

active

052703096

ABSTRACT:
4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, and their pharmaceutically acceptable salts, are potent specific antagonists of N-methyl-D-aspartate (NMDA) receptors and are therefore useful in the treatment of neurodegenerative disorders. 4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, other than carboxy or C.sub.1-6 alkoxycarbonyl, are novel compounds, as also are compounds of formula II ##STR1## wherein R.sup.2 represents carboxy or a group convertible thereto in vivo, R.sup.6 is hydrogen and R.sup.5 and R.sup.7 represent C.sub.1-6 alkyl or halogen, provided that R.sup.5 and R.sup.7 are not simultaneously chlorine or simultaneously bromine; a process for preparing the novel compounds is described, as also are pharmaceutical compositions containing the novel compounds.

REFERENCES:
patent: 4328230 (1982-05-01), Brown et al.
patent: 5026700 (1991-06-01), Harrison et al.
patent: 5028707 (1991-07-01), Nichols et al.
Evans, et al., Br. J. Pharmac., vol. 91 (1987) pp. 531-537.
Mutschler Arzneimittelwirkungen 5th Edition (1986), pp. 555-566.
Perkins, et al., Chem. Abs. 99, No. 25 (Dec. 19, 1983) p. 139, 206826b.
Neumuller Rompps Chemie-Lexikon (8th Ed.) 3 p. 2296 (1983).
Daeniker, et al., Chem. Abs. 54, No. 538 (1960).
Heindel, et al., J. Med. Chem. II, pp. 1218-1221 (1968).

Affiliated with

Also associated with

Rating

Kynurenic acid derivatives useful in the treatment of neurodegen does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Kynurenic acid derivatives useful in the treatment of neurodegen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Kynurenic acid derivatives useful in the treatment of neurodegen will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1705722