KUZ, a novel family of metalloproteases

Details KUZ, a novel family of metalloproteases KUZ, a novel family of metalloproteases

1997-08-27

1999-08-10

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 23, 4352523, 4353201, 435212, 435226, 536 232, C12Q 168, C12Q 137, C12N 948, C07H 2104

Patent

active

059357924

ABSTRACT:
Members of a novel family of polypeptides, the KUZ family, are metalloproteases involved in neuronal partitioning and neuronal development. The invention provides KUZ poylpeptides, antibodies that bind the KUZ polypeptides, KUZ encoding nucleic acids, methods for identifying cells expressing the KUZ polypeptides, methods of identifying ligands that bind to the subject proteins and methods of blocking KUZ polypeptide/ligand interactions

REFERENCES:
Hillier et al. Oct. 24, 1995. The WasU-Merck EST Project. EST-STS accession H69389.
Hillier et al. Mar. 15, 1997. The WashU-Merck EST Project. EST-STS accession T79341.
Pan et al. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neugenesis. Cell. Jul. 25, 1997, vol. 90 pp. 271-280.
Yedvobnick. Snake venom, fertilization and neurogenesis. TINS. Dec., 1996. vol. 19, No. 12, pp. 528-530.

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