Kunitz domain polypeptide and materials and methods for making i

Details Kunitz domain polypeptide and materials and methods for making i Kunitz domain polypeptide and materials and methods for making i

1999-05-26

2000-07-11

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

A61K 3800, C07K 200

Patent

active

060874732

ABSTRACT:
Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a sequence of amino acid residues as shown in SEQ ID NO:5, wherein the sequence is at least 90% identical to SEQ ID NO:2. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.

REFERENCES:
patent: 5780265 (1998-07-01), Dennis et al.
patent: 5795865 (1998-08-01), Markland et al.
patent: 5795954 (1998-08-01), Lazarus et al.
patent: 5834244 (1998-11-01), Dennis et al.
patent: 5880256 (1999-03-01), Dennis et al.
EMBL Genbank Accession No. AI217375, Oct. 28, 1998.
EMBL Genbank Accession No. AI554767, Mar. 25, 1999.
LIFESEQ198 Information Results (INC251157), Incyte Pharmaceuticals, Inc., 1995.

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