Knockout mutant mouse for DARPP-32 and use thereof

Details Knockout mutant mouse for DARPP-32 and use thereof Knockout mutant mouse for DARPP-32 and use thereof

1996-05-17

1998-07-07

Stanton, Brian R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

424 91, 424 92, 4351723, 435325, 800 2, 800DIG1, 800DIG2, 800DIG4, 800DIG6, 935 34, 935 70, C12N 500, C12N 506, C12N 1509, A61K 4900

Patent

active

057771952

ABSTRACT:
A knockout mouse containing a non-functional allele for the gene that naturally encodes and expresses functional DARPP-32 is disclosed. This mouse contains two non-functional alleles for the gene that naturally encodes and expresses functional DARPP-32, and therefore is unable to express functional DARPP-32. This mouse finds utility as a screening model for potential therapeutic agents useful in the treatment of schizophrenia, Parkinson's disease, and the treatment of addictions, especially those involving drugs of abuse.

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