Knockout mice and their progeny with a disrupted hepsin gene

Details Knockout mice and their progeny with a disrupted hepsin gene Knockout mice and their progeny with a disrupted hepsin gene

1997-12-30

1999-11-09

Stanton, Brian R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

800 21, 800 22, 800 25, 800 3, 435455, 435463, 4353201, 435325, 530350, 526 235, C12N 1509, C12N 1563, C12N 1500, C12N 500

Patent

active

059818301

ABSTRACT:
The present invention provides a transgenic mouse comprising a disrupted hepsin gene. In particular, the invention provides methods of making the transgenic mouse comprising the disrupted hepsin gene by utilizing a hepsin targeting vector for homologous recombination in mouse embryonic stem cells. Also, nucleotide and amino acid hepsin sequences are disclosed.

REFERENCES:
Leytus et al., "A Novel Trypsin-like Serine Protease (Hepsin) with a Putative Transmembrane Domain Expressed by Human Liver and Hepatoma Cells", Biochemistry, vol. 27, pp. 1067-1074, 1988.
Kazama et al., "Hepsin, a Putative Membrane-associated Serine Protease, Activates Human Factor VII and Initiates a Pathway of Blood Coagulation on the Cell Surface Leading to Thrombin Formation",J. of Biol. Chem., 270(1):66-72, 1995.
Torres-Rosado et al., "Hepsin, a putative cell-surface protease, is required for mammalian cell growth", Proc. Natl. Acad. Sci.USA, vol. 90, pp. 7181-7185, Aug. 1993.
Capecchi, Scientific American, 270(3):34-41.
Darrow et al., Thrombosis and Haemostasis, 76(6):860-866.

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