Klebsiella capsular polysaccharide vaccine

Details Klebsiella capsular polysaccharide vaccine Klebsiella capsular polysaccharide vaccine

1986-03-27

1988-07-05

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435852, 536 11, 536123, 536127, 536128, C08B 3700, A61K 31715, A61K 39108

Patent

active

047553812

ABSTRACT:
The present invention relates to immunogenic preparations of Klebsiella species serotype-specific capsular polysaccharides. The invention involves the treatment of Klebsiella capsular polysaccharides in dilute sodium hydroxide to detoxify co-purified toxic lipopolysaccharides and to yield immunogenic vaccine preparations safe for parenteral administration to humans. The polyvalent vaccines prepared by use of the above vaccine are effective at providing protection against infections caused by Klebsiella species bacilli.

REFERENCES:
patent: 4663160 (1987-05-01), Tsay et al.
patent: 4711779 (1987-12-01), Porro et al.
J. Biol. Chem. 256, 14, 1981, 7305-7310, Seid et al.
Infect. Imm. 24: 476-482 (1979), Riottot et al.
Infect. Immun. 31:71-77 (1981), Riottot et al.
Infect-Immun. 32:420-426 (1981) Fournier et al.
Infect. Immun. 45:139-142 (1984), Cryz, Jr. et al.
Infect. Immun. 50:225-230 (Oct. 1985), Crys. Jr. et al.
Kreger et al,--Gram-Negative Bacteremia--Mar., 1980, pp. 322-355.
Robert et al.--Infect Immun. 54:365-370, 1986.

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