Kits for flurotometric analyses

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

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C435S325000, C435S317100, C536S024300, C536S055000, C540S472000, C540S465000

Reexamination Certificate

active

07820783

ABSTRACT:
Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.

REFERENCES:
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patent: 5439797 (1995-08-01), Tsien et al.
patent: 6074834 (2000-06-01), Slezak et al.
patent: 6926885 (2005-08-01), Licha et al.
David E. Wolf, “Determination of the Sidedness of Carbocyanine Dye Labeling of Membranes,” Biochemistry, (1985), vol. 24, pp. 582-585.
Ping Chen, et al., Structure and Solvent Effective on the Photostability of Indolenine Cyanine Dyes,“Elsevier Science Ltd., Dyes and Pigments,” (1999), vol. 41, pp. 227-331.

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