Kits for assays of rapid screening of diabetes

Details Kits for assays of rapid screening of diabetes Kits for assays of rapid screening of diabetes

2007-02-15

2008-09-30

Gitomer, Ralph (Department: 1657)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving glucose or galactose

Reexamination Certificate

active

07429462

ABSTRACT:
The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.

REFERENCES:
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patent: WO 02/03855 (2002-01-01), None
patent: WO 02/087429 (2002-11-01), None
European Search Report.
A Fluorescence-Based Glucose Biosensor Using Concanavalin A and Dextran Encapsulated in a Poly (ethylene gylcol) Hydrogel, Ryan J. Russell and Michael V. Pishko, Analytical Chemistry, vol. 71, No. 15, Aug. 1, 1999.

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