Kits and method for determining the risk of adverse effects...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091200

Reexamination Certificate

active

07943311

ABSTRACT:
A method for determining the risk of adverse effects of irinotecan (CPT-11), a synthetic anticancer drug, by detecting polymorphisms in the TATA box within the promoter region of the UDP-glucuronosyl transferase gene. A kit for detecting the adverse effects of irinotecan containing at least one pair of nucleic acid probes.

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Han et al, Journal of Clinical Oncology, 2006, 24(15), pp. 2237-2244.
Smith at al, Toxicology in Vitro, 2006, 20, pp. 163-175.
Yuichi Ando, et al., “Polymorphisms of UDP-Glucuronosyltransferase Gene and Irinotecan Toxicity: A Pharamacogenetic Analysis1”, Cancer Research, vol. 60, Dec. 15, 2000, pp. 6921-6926.

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