Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1989-09-27
1993-02-02
Johnston, Jill A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 11, 435962, 436548, 436825, C12Q 160, G01N 33577
Patent
active
051837382
ABSTRACT:
A kit and a method for detecting denatured lipoproteins is disclosed. The method comprises: adding to a sample a mixture of (i) an affinity gel with which a monoclonal antibody for apoprotein A-I is coupled and (ii) an affinity gel with which a monoclonal antibody for apoprotein B-100 is coupled; removing apoprotein A-I and apoprotein B-100 in the sample by combining the apoprotein A-I and apoprotein B-100 with the affinity gels; and measuring an amount of lipoproteins in the residue. The kit comprises a mixture of (i) and (ii) as an essential component. The kit and the method is useful for the clinical investigation and diagnosis of abnormal lipid metabolism which can be a cause of heart diseases (e.g. cardiac infarction), diabetes, and various types of atherosclerosis diseases.
REFERENCES:
patent: 4211530 (1980-07-01), Goverde et al.
patent: 4828986 (1989-05-01), Smith et al.
patent: 4966837 (1990-10-01), Brown et al.
Chemical Abstracts, vol. 108, No. 13, Mar. 1988 T. Saito et al.
Chemical Abstracts, vol. 107, No. 17, Oct. 1987, S. Ksahara, et al. p. 360.
Chemical Abstracts, vol. 106, No. 26, Jun. 1987, T. Mori et al.
Adachi Masakazu
Murata Kimiyo
Saitou Toshimitu
Tamura Aki
Japan Immuno Research Laboratories Co., Ltd.
Johnston Jill A.
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