Kit for preventing or treating arterial dysfunction resulting fr

Details Kit for preventing or treating arterial dysfunction resulting fr Kit for preventing or treating arterial dysfunction resulting fr

1988-12-08

1990-09-11

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

514573, A61M 500

Patent

active

049558781

ABSTRACT:
A kit for preventing or treating arterial dysfunction resulting from an angioplasty procedure and particularly, in myocardial angioplasty procedures in human beings. The kit provides the materials necessary to introduce a selected amount of an intraarterial prostaglandin compound into an artery, such as a coronary artery, in which an angioplasty procedure is to occur and an intravenous prostaglandin compound. The prostaglandin compound will provide cyto-protection and provide antithrombotic effects and antiplatelet effects and antispasmatic effects. A composition is also provided for reducing dysfunction in angioplasty procedures and comprises a selected amount of a carrier and a prostaglandin compound carried in a specified amount and which carrier does not alter the prostaglandin compound and releases the prostaglandin compound at a rate sufficient to dilate blood vessels to thereby produce the required efficacy. The kit is a prepackaged combination of components which provides for the complete administration of the prostaglandin compound before, during and after the angioplasty procedure.

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patent: 4558037 (1985-12-01), Chan et al.
patent: 4734424 (1988-03-01), Hall et al.
Cragg, A. et al., "Vessel Wall Arachidonate Metabolism After Angioplasty: Possible Mediators of Postangioplasty Vasospasm", American Journal of Cardiology, vol. 51, pp. 1441-1445, (5-1-83).
Zollikofer, C. L. et al., "Interventional Radiology-Prostaglandins and Angioplasty", Radiology, vol. 149, No. 3, pp. 681-685, Dec. 1983.
Faxon et al., "Effect of Antiplatelet Therapy on Restenosis After Experimental Angioplasty", American Journal of Cardiology, vol. 53, pp. 72C-76C, (6-15-84/Suppls.).

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