Kit for preparing radiodiagnostic examination compositions

Details Kit for preparing radiodiagnostic examination compositions Kit for preparing radiodiagnostic examination compositions

1990-08-17

1991-06-04

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

206569, A61K 4902, B65D 6900

Patent

active

050212206

ABSTRACT:
The invention relates to a method of preparing a chlorinated, brominated, radiobrominated, iodinated and/or radio-iodinated aromatic or heteroaromatic compound, in which the (hetero)aromatic nucleus optionally comprises one or more additional substituents, by reacting the corresponding halogenated or diazonium-substituted compound in the presence of a water-soluble acid and of copper ions as a catalyst with a likewise water-soluble chloride, bromide radiobromide, iodide or radio-iodide, in which the reaction is carried out in the presence of one or more reduction agents, which are stable in acid medium, in a quantity exceeding the quantity of catalyst. The invention also relates to a composition suitable for diagnostic examination and to a kit for the preparation thereof. The invention further relates to a method and an equipment for the preparation of said composition.

REFERENCES:
patent: 4031198 (1977-06-01), Jackson et al.
patent: 4032625 (1977-06-01), Subramanian et al.
patent: 4942231 (1990-07-01), Mertens

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