Kit for preparing a technetium-99m myocardial imaging agent

Details Kit for preparing a technetium-99m myocardial imaging agent Kit for preparing a technetium-99m myocardial imaging agent

1991-04-04

1992-05-12

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

252 1, 206569, A61K 4902, B65D 6900

Patent

active

051125943

ABSTRACT:
A myocardial imaging agent for use in humans comprising a Tc(III) complex ligated in a planar position by a tetradentate ligand having incorporated therein four hard atotms and two furanone rings and in the axial positions by phosphines containing dioxanyl or ether moieties. The agent exhibits improved biodistribution, improved labeling and extremely rapid blood clearance following administration to a human. The agent has high myocardial uptake accompanied with exceptionally rapid hepatobilary clearance and extensive renal clearance to give sufficiently high heart/liver and heart/lung ratio that provide nearly ideal myocardial images in humans. A kit for producing the myocardial imaging agent is provided.

REFERENCES:
patent: 4917879 (1990-04-01), Deutsch et al.
patent: 4957728 (1990-09-01), Deutsch et al.

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