Kit for prenatal screening for Down's syndrome

Details Kit for prenatal screening for Down's syndrome Kit for prenatal screening for Down's syndrome

1995-06-07

1997-02-25

Green, Lora M.

Chemistry: analytical and immunological testing

Immunochemical pregnancy determination

435 793, 435975, 436814, 436817, 436818, G01N 3353, G01N 3374, G01N 3376

Patent

active

056058438

ABSTRACT:
Kits are provided for prenatal screening tests for risk of Down's syndrome which are carried out on a maternal serum sample obtained before the beginning of the third trimester of pregnancy. The kits contain immunoassay means to determine alpha-fetoprotein, unconjugated oestriol, human chorionic gonadotrophin, and/or dehydroepiandrosterone sulfate (DHEAS).

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Prenatal Diagnosis, vol. 7, 623-630 (1987), Bogart et al "Abnormal Maternal Serum Chorionic Gonadotropin Levels . . . ".
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American Journal of Obstetrics and Gynecology, vol. 148, No. 7, Apr. 1, 1984 Merkatz et al, pp. 886-894, "An Association Between Low Maternal Serum . . . ".
"Maternal Serum Alpha-Fetoprotein, Age, and Down Syndrome Risk", Palomaki et al 1986, Foundation for Blood Research, vol. 156, No. 2, pp. 460-463.
The Lancet, Oct. 14, 1972, Jorgensen et al, "Low Urinary Oestriol Excretion During Pregnancy in Women . . . " pp. 782-784.
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