Kit for determining blood platelet stress

Details Kit for determining blood platelet stress Kit for determining blood platelet stress

1986-03-27

1991-04-23

Richman, Barry S.

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Sample mechanical transport means in or for automated...

435 13, 435810, 436 63, C12Q 156, G01N 3348

Patent

active

050098470

ABSTRACT:
A kit is provided for measuring chemical and physical stresses on the blood platelets of a human patient by measuring reduction in ATP (adenosine triphosphate) and ADP (adenosine diphosphate) concentrations while measuring increases in the ATP degradation products HYPX (hypoxanthine) and the AMP (adenosine monophosphate). The kit is useful for measuring a human patient's risk to internal stress such as reduction in the size of blood vessels, to response to various environmental changes as well as to a variety of treatments including drug treatment, risk of malignant hyperthermia in response to anesthetic administration or in response to vascular or organ transplant.

REFERENCES:
Solomons et al; Platelet Biochemistry and Function--Possible Use in Evaluating Biocompatibility, CA84(17):118071m, 1975.
Ericson et al; Plasma Concentration and Renal Excretion of Adenine and 2,8-Dihydroxyadenine After Administration of Adenine in Man, CA92(17):140398k, 1980.
Turturro et al; HPLC Method for the Separation of the Halogenated Pyrimidine 5-Bromo-2'-Deoxyuridine from its Metabolites; J. of Chrom., 252(1982), pp. 335-337.
Fisher Scientific 1983; Products catalog 1982, p. 115.

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