Kit for detecting Her-2/neu gene by site-specific metal...

Details Kit for detecting Her-2/neu gene by site-specific metal... Kit for detecting Her-2/neu gene by site-specific metal...

2007-02-27

2007-02-27

Gitomer, Ralph (Department: 1655)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving oxidoreductase

C435S975000

Reexamination Certificate

active

10658609

ABSTRACT:
Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal. Additionally disclosed is how to use enzymes to accumulate metal particles. The alteration of metal particles by enzymes interacting with the organic shell of the particles is also described. These methods enable a wide range of applications including sensitive detection of genes and proteins, use as probes for microscopy, nanofabrication, biosensors, and remediation.

REFERENCES:
patent: 5116734 (1992-05-01), Higgs et al.
patent: 6358682 (2002-03-01), Jaffee et al.
patent: 6911306 (2005-06-01), Vertino
patent: 2005/0074457 (2005-04-01), Kamal et al.
Press M. et al. Evaluation of Her-2
eu Gene Amplification and Overexpression. J of Clinical Onoclogy 20(14)3095-3105, Jul. 15, 2002.

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