Kit for assaying activation of terminal complement cascade

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 18, 435 19, 435 23, 436540, 436821, G01N 3353

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active

048206350

ABSTRACT:
A kit for assaying the activation of terminal complement cascade is disclosed. The kit includes a plurality of containers which contain a first antibody having a specificity for poly C9 neoantigen. The containers further have a second antibody which is different from the first antibody and has a specificity for a constituent of terminal complement cascade. A third antibody is optionally present which recognizes the second antibody. The kit also includes a substrate splitting enzyme, a substrate for the enzyme which produces a color reaction when split, and a SCb-9 standard microtiter plate. Pipettes and instructions for performing the assay are also included.

REFERENCES:
Bhakdi et al., (1983) Journ. of Immun. Meth. 57:283-289.
Falk et al., (1985) N. Engl. Journ. Med. 312:1594-1599.
Mollnes et al. (1984) Scand. J. Immunol. 20:157-166.
Podack et al., (1984) Molecular Immun. 21:589-603.
Sanders et al., (Abstract) Cellular Interactions of Complement II.
Fed. Proc. 44 (1985) and Clinical Research 33 (1985).
Sanders et al., Chem. Abst. vol. 104 (1986) p. 86596z.

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