Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1987-07-31
1989-04-11
Rosen, Sam
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 18, 435 19, 435 23, 436540, 436821, G01N 3353
Patent
active
048206350
ABSTRACT:
A kit for assaying the activation of terminal complement cascade is disclosed. The kit includes a plurality of containers which contain a first antibody having a specificity for poly C9 neoantigen. The containers further have a second antibody which is different from the first antibody and has a specificity for a constituent of terminal complement cascade. A third antibody is optionally present which recognizes the second antibody. The kit also includes a substrate splitting enzyme, a substrate for the enzyme which produces a color reaction when split, and a SCb-9 standard microtiter plate. Pipettes and instructions for performing the assay are also included.
REFERENCES:
Bhakdi et al., (1983) Journ. of Immun. Meth. 57:283-289.
Falk et al., (1985) N. Engl. Journ. Med. 312:1594-1599.
Mollnes et al. (1984) Scand. J. Immunol. 20:157-166.
Podack et al., (1984) Molecular Immun. 21:589-603.
Sanders et al., (Abstract) Cellular Interactions of Complement II.
Fed. Proc. 44 (1985) and Clinical Research 33 (1985).
Sanders et al., Chem. Abst. vol. 104 (1986) p. 86596z.
Frank Michael M.
Hammer Carl H.
Joiner Keith A.
Sanders Martin E.
Rosen Sam
The United States of America as represented by the Department of
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