Kit and method of screening wilson's disease

Details Kit and method of screening wilson's disease Kit and method of screening wilson's disease

2004-09-07

2008-08-05

Gupta, Anish (Department: 1654)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S007100, C435S007200, C435S007920, C435S070210, C435S025000, C435S028000, C435S338000, C435S975000

Reexamination Certificate

active

07407743

ABSTRACT:
The present invention relates to a method for measuring a ceruloplasmin concentration, and more particularly, to a method for measuring a ceruloplasmin in a blood spot based on a standard concentration curve obtained through an enzyme-linked immunosorbent assay (ELISA) or a dissociation-enhanced time-resolved fluoroimmunoassay using a ceruloplasmin-specific polyclonal antibody or a ceruloplasmin-specific monoclonal antibody.

REFERENCES:
patent: 5491066 (1996-02-01), Hiyamuta et al.
patent: 6806044 (2004-10-01), Hahn et al.
Ohura T, Abukawa D, Shiraishi H, Yamaguchi A, Arashima S, Hiyamuta S, Tada K, Linuma K, Pilot study of screening for Wilson disease using dried blood spots obtained from children seen at outpatient clinics, J. Inher. Met. Dis., 1999, 22: 74-80.
Hiyamuta S and Ito K, Monoclonal Antibody Against the Active Site of Caeruloplasmin and the ELISA System Detecting Active Caeruloplasmin, Hybridoma, 1994, 13(2): 139-141.
Hahn S, Lee SY, Jang YJ, Kim SN, Shin HC, Park SY, Kang JH and You ES, Development of a Screening Kit for Early Diagnosis and Prevention of Wilson's Disease, Journal of Korean Pediatrics Association, 2001, 44(12):1374-1380.
Si Houn Hahn et al., “Pilot study of mass screening for Wilson's disease in Korea”,Molecular Genetics and Metabolism, vol. 76, 2002, pp. 133-136.

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