Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1990-11-28
1993-03-16
Naff, David M.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
4241951, C12N 120, A61K 3574
Patent
active
051942577
ABSTRACT:
Improved treatment of superficial bladder tumors through the administration by intravesical instillation of bacillus Calmette-Guerin is realized through the use of therapeutic composition comprising bacillus Calmette-Guerin (BCG) suspended in a 0.15 M sodium chloride solution containing a buffer to maintain the pH of the solution in the range 6.6 to 7.4, preferably 7.0. A kit and method are provided whereby such a composition may be employed to maximize intravesical attachment of BCG for improved efficacy.
Hudson M'Liss A.
Ratliff Timothy L.
Ritchey Julie K.
Naff David M.
The Jewish Hospital of St. Louis
Witz Jean C.
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