Kinetic resolution of pyridazinones using lipase

Details Kinetic resolution of pyridazinones using lipase Kinetic resolution of pyridazinones using lipase

1990-07-20

1991-10-01

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435122, 435198, 544239, C12P 4100

Patent

active

050533380

ABSTRACT:
A kinetic resolution of pyridazinones of the following formula (A): ##STR1## where R.sup.1 is alkyl by enzymatic hydrolysis results in good optical purity of the phenolic product. This is significant considering the distance in the molecule (A) from the C-5 chiral center to the site of hydrolysis.

REFERENCES:
Kalaritis, Panos et al., Kinetic Resolution of 2-Substituted Esters Catalyzed by a Lipase Ex., J. Org. Chem. 1990, 55, 812-815.
Whitesides, George M., Enzymes as Catalysts in Synthetic Organic Chemistry, vol. 24, No. 8, Aug. 1985, 617-718.

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