Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-09-28
2000-01-11
Achutamurthy, Ponnathapu
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4352523, 435325, 4353201, 435 691, 536 231, C12Q 168, C12P 2106, C12N 120, C12N 1500, C12N 500
Patent
active
060134542
ABSTRACT:
The invention provides a human kinesin-like motor protein (KLIMP) and polynucleotides which identify and encode KLIMP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of KLIMP.
REFERENCES:
Moore, J.D. and Endow, S.A., "Kinesin proteins: a phylum of motors for microtubule-based motility", Bioessays 18 (3): 207-219 (1996).
Hoyt, A.M., "Cellular roles of kinesin and related proteins", Curr. Opin. Cell Biol. 6: 63-68 (1994).
Hurd, D.D. and Saxton, W.M., "Kinesin Mutations Cause Motor Neuron Disease Phenotypes by Disrupting Fast Axonal Transport in Drosophila", Genetics 144: 1075-1085 (1996).
Dorner, C. et al., (Direct Submission), GenBank Sequence Database (Accession 2738149), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 2738149), Aug. 4, 1998.
Dorner, et al., "Characterization of KIF1C, a New Kinesin-like Protein Involved in Vesicle Transport from the Golgi Apparatus to the Endoplasmic Reticulum", J. Biochem. Chem. 273(32): 20267-20275 (1998).
Dorner, C. et al., (Direct Submission), GenBank Sequence Database (Accession U91329), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 2738148) Aug. 4, 1998.
Corley Neil C.
Guegler Karl J.
Patterson Chandra
Tang Y. Tom
Achutamurthy Ponnathapu
Incyte Pharmaceuticals Inc.
Muenzen Colette C.
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