Kinases and uses thereof

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase

Reexamination Certificate

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Reexamination Certificate

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07655432

ABSTRACT:
Novel kinase polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length kinase proteins, the invention further provides isolated kinase fusion proteins, antigenic peptides, and anti-kinase antibodies. The invention also provides kinase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

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Colman, Research in Immunology, 1994; 145(1): 33-36.
NCBI Entrez Protein Query, GenBank Report for Accession No. AAB71795, Federspiel et al., Direct Submission, Submitted Jun. 5, 1997. Amino Acid Residues 1-645 are SEQ ID Nos. 15 and 16.
NCBI Entrez Protein Query, GenBank Report for Accession No. AAB65490, Rounsley et al., Direct Submissions, Submitted Apr. 4, 1997. Amino Acid Residues 1-604 are SEQ ID No. 17.
NCBI Entrez Protein Query, GenBank Report for Accession No. AAC47047, Wilson et al., “2.2 Mb of Contiguous Nucleotide Sequence from Chromosome III ofC. elegans,” Nature, 1994 pp. 32-38, vol. 368; Waterston, Direct Submission, Submitted Apr. 8, 1994. Amino Acid Residues 1-328 are SEQ ID Nos. 18.
NCBI Entrez Protein Query, GenBank Report for Accession No. P80192, Dorow et al., “Identification of a New Family of Human Epithelial Protein Kinase Containing Two Leucine/Isoleucine-zipper Domains,” Eur. J. Biochem., 1993, pp. 701-710, vol. 213. Amino Acid Residues 1-394 are SEQ ID No. 19.
Database EST, Accession No. AA740847, NCI-CGAP http://www.ncbi.nlm.nih.gov
cicga;, National Cancer Genome Project (CGAP), Tumor Gene Index, Feb. 7, 1998. See their sequence for having at least 15 nucleotides of SEQ ID No. 1 and having the potential of encoding 15 amino acids (fragments) of SEQ ID O:2.
Colman, Research in Immunology, 1994; 145(1):33-36.

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