Kinases and uses thereof

Details Kinases and uses thereof Kinases and uses thereof

2005-02-22

2005-02-22

Monshipouri, Maryam (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C530S350000, C435S006120, C435S320100, C435S325000, C435S252300

Reexamination Certificate

active

06858418

ABSTRACT:
Novel kinase polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length kinase proteins, the invention further provides isolated kinase fusion proteins, antigenic peptides, and anti-kinase antibodies. The invention also provides kinase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
patent: 5663314 (1997-09-01), Seger et al.
patent: 5817479 (1998-10-01), Au-Young et al.
patent: WO 9964576 (1999-12-01), None
patent: WO 0006728 (2000-02-01), None
NCBI Entrez Protein Query, GenBank Report for Accession No. AAB71795, Federspiel, et al., Direct Submission, Submitted Jun. 5, 1997. Amino Acid Residues 1-645 are Seq ID Nos:15 and 16.
NCBI Entrez Protein Query, GenBank Report for Accession No. AAB65490, Rounsley et al., Direct Submissions, Submitted Apr. 4, 1997. Amino Acid Residues 1-604 are Seq ID No:17.
NCBI Entrez Protein Query, GenBank Report for Accession No. AAC47047, Wilson, et al., “2.2 Mb of Contiguous Nucleotide Sequence from Chromosome III of C. elegans,” Nature, 1994 pp. 32-38, vol. 368; Waterston, Direct Submission, Submitted Apr. 8, 1994. Amino Acid Residues 1-328 are Seq ID No:18.
NCBI Entrez Protein Query, GenBank Report for Accession No. P80192, Dorow, et al., “Identification of a New Family of Human Epithelial Protein Kinases Containing Two Leucine/Isoleucine-zipper Domains,” Eur. J. Biochem., 1993, pp. 701-710, vol. 213. Amino Acid Resideus 1-394 are Seq ID No:19.
Blast N Analysis of Seq ID No:1 vs. Nucleotide Patent Database.
Blast X Analysis of Seq ID No:2 vs. PNU Database.
Blast X Analysis of Seq ID No:2 vs. Protein Patent Database.
Blast N ORF (open reading frame) Analysis of Seq ID No:1 vs. Nucleotide dbEST, Nucleotide Patent Preview, and Nucleotide Patent Databases; and Blast X Analysis of Seq ID No:2 vs. Protein and Protein Patent Database.
Blast N Analysis of Seq ID No:3 vs. Nucleotide Patent and Nucleotide Patent Preview Databases.
Blast X Analysis of Seq ID No:4 vs. PNU and Protein Patent Databases.
Blast N. Analysis of ORF of Seq ID No:3 vs. Nucleotide, dbEST, Nucleotide Patent Preview, and Nucleotide Patent Databases; and Blast X Analysis of Seq ID No:4 vs. Protein and Protein Patent Databases.
Blast N Analysis of ORF of Seq ID No:5 vs. Nucleotide, dbEST, Nucleotide Patent Preview, and Nucleotide Patent Databases; and Blast X Analysis of Seq ID No:6 vs. Protein and Protein Patent Databases.
Blast N Analysis of ORF of Seq ID No:7 vs. Nucleotide, dbEST, Nucleotide Patent Preview, and Nucleotide Patent Databases; and Blast X Analysis of Seq ID No:8 vs. Protein and Protein Patent Databases.
Blast N Analysis of ORF of Seq ID No:9 vs. Nucleotide, dbEST, Nucleotide Patent Preview, and Nucleotide Patent Databases; and Blast X Analysis of Seq ID No:10 vs. Protein and Protein Patent Databases.
Blast N Analysis of ORF (partial) of Seq ID No:11 vs. Nucleotide, dbEST, Nucleotide Patent Preview, and Nucleotide Patent Databases; and Blast X Analysis of Seq ID No:12 vs. Protein amd Protein Patent Databases.
Blast N Analysis of ORF of Seq ID No:13 vs. Nucleotide, dbEST, Nucleotide Patent Preview, and Nucleotide Patent Databases; and Blast X Analysis of Seq ID No:14 vs. Protein and Protein Patent Databases.
Database EST, Accession No. AA448898, Hillier et al., ‘WashU-Merck EST Project,’ Jun. 4, 1997. See the alignment of having at least 15 consecutive nucleotides of Seq ID No:1 and having the potential of encoding 15 amino acids of Seq ID No:2.
Database EST, Accession No. AA740847, NCI-CGAP http://www.ncbi.nlm.nih.gov
cicga;, ‘National Cancer Institute, Cancer Genome Project (CGAP), Tumor Gene Index,’ Feb. 7, 1998. See their sequence for having at least 15 nucleotides of Seq ID No:1 and having the potential of encoding 15 amino acids (fragments) of Seq ID No:2.

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